故事发生在一个虚拟的奇幻世界之中。在这里，相对应的两人将手牵在一起，所产生的心灵连结“宁录”能够成为拥有着强大力量的武器。在传说中，这个世界上存在着掌控着一切的神，只要将神打败，就能够实现内心最强烈的愿望。长久以来，握手者们都将打败神作为目标，不断地战斗着，而一切因果的汇聚点就在大阪。高槻手纲（齐藤壮马 配音）是对机械十分着迷的男子高中生，一次偶然中，他在研究室里邂逅了昏睡中的少女芥川小代理（诸星堇 配音）。手纲牵住了小代理的手，想不到小代理竟然从昏睡中醒来，两人成为了搭档。

Hand Shakers——将手牵起，利用从深层心理诞生的武器“宁录”互相战斗的人们。为了实现自己的“愿望”，从而见到神，将神打破，众多的Hand Shakers以那个顶点为目标，互相竞争。存在于那尽头的事物是——。——大阪擅长摆弄机械的高中生·手纲，接受了某个修理委托而来到大学的研究室。他在那里，与一直睡在床上的一位少女·小代理相遇了。如同被什么引导一般触碰到小代理指尖的手纲，听到了从某处倾注而下的声音。——跨越众多战斗，超越试炼之人。接受启示之人。企图见到我，挑战我之人。其为“Hand Shaker”——由于在眼前延伸的异质世界“金字形神塔”而困惑的手纲。刹那间，手纲和小代理遭到了某人的袭击——。企图见到神的诸多Hand Shakers，阻挡在手纲和小代理的面前。赌上他们各自的“愿望”……。去守护吧，用这双手。

Studio head Joe Mulholland promises his dying producer and mentor, Saul Gritz, to adapt a popular sex manual into a film, despite his better judgment. Unable to figure out how to turn the nonfiction book into a narrative movie, Mulholland enlists the services of Herb Dorman, a screenwriter of popular romantic films with a bad marriage, and volatile director Sid Spokane to help him create a movie.

Andy, Sandy, Nat and Shah head out to the forest edge for a night of scientific adventure. They were hanging out in the tent when suddenly, they hear a loud crash. Nat brings home a metal sphere that he found in the forest and shows it to the Sky Shakers. Meanwhile, a furry creature makes its way to Andy's house in search of the sphere that Nat found. Little did anyone know that a group of Henchmen have just landed in the forest of Singapore, in search of the furry creature.

Only a formal handshake separates two politicians from a sealed contract. But as both stubbornly try to gain the upper hand within the gesture, their grim intransigence takes on a monstrous life of its own.

Pre 1979 in Aotearoa, using Sign Language in schools was banned. This true story of two girls breaking the rules in the name of friendship sheds light on the history and realities of being deaf.

A couple who had been married for forty years now prepare for death together as the wife gets cancer and has only two months to live.

When an injury to her hand threatens her career, a violin virtuoso seeks out a vascular surgeon in Dresden, who takes the rather unworldly musician under her wing. Following various family disappointments and setbacks, the resolute doctor travels with her new friend to the latter’s homeland, Latvia.

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